Raj Putatunda,John R. Bethea,Wen-Hui Hu.[J].中华创伤杂志英文版,2018,21(3):125-136
Potential immunotherapies for traumatic brain and spinal cord injury
  
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KeyWord: Brain injurySpinal cord injuryInnate and adaptive immunityInflammatory responseImmunotherapySecondary injury
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Author NameAffiliation
Raj Putatunda Center for Metabolic Disease Research, Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA, USA 
John R. Bethea Department of Biology, Drexel University, Philadelphia, PA, USA 
Wen-Hui Hu Center for Metabolic Disease Research, Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA, USA 
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Abstract:
      Traumatic injury of the central nervous system (CNS) including brain and spinal cord remains a leading cause of morbidity and disability in the world. Delineating the mechanisms underlying the secondary and persistent injury versus the primary and transient injury has been drawing extensive attention for study during the past few decades. The sterile neuroinflammation during the secondary phase of injury has been frequently identified substrate underlying CNS injury, but as of now, no conclusive studies have determined whether this is a beneficial or detrimental role in the context of repair. Recent pioneering studies have demonstrated the key roles for the innate and adaptive immune responses in regulating sterile neuroinflammation and CNS repair. Some promising immunotherapeutic strategies have been recently developed for the treatment of CNS injury. This review updates the recent progress on elucidating the roles of the innate and adaptive immune responses in the context of CNS injury, the development and characterization of potential immunotherapeutics, as well as outstanding questions in this field.
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